Shalom Life | August 02, 2014

Study Sheds Light on Crohn’s Disease in Ashkenazi Jews

Five New Genetic Mutations Discovered

By: Leonard Carl

Published: May 15th, 2012 in Health » World

Study Sheds Light on Crohn’s Disease in Ashkenazi Jews

Ashkenazi Jews are four times more likely to be affected by Crohn’s disease than any other group.

Crohn’s is an inflammatory bowel disease (IBD) which affects the intestines, but may occur anywhere from the mouth to the anus. While the exact cause of Crohn's disease is unknown, we do know that it’s an autoimmune disorder which occurs when the body's immune system mistakenly attacks and destroys healthy body tissue.

Up until now, the reason for the high likelihood of infection within the Ashkenazi group was unknown, but according to an online science journal, researchers have shed light on this phenomenon with the discovery of five new genetic mutations.

According to the March 8th issue of PLoS (Public Library of Science), Prof. Inga Peter, a geneticist at Mount Sinai, led an international research team to search for unique genetic risk factors in Ashkenazi Jews. Peter and her team compared 1,878 Ashkenazi Jews with Crohn’s disease with 4,469 Ashkenazi Jews without it, using DNA samples to determine their genetics. The team found 12 of the known risk variants, but also uncovered five new genetic risk regions on chromosomes (5q21.1, 2p15, 8q21.11, 10q26.3 and 11q12.1).

Funded by the New York Crohn’s Disease foundation, the research team also evaluated previous findings in non- Jewish Europeans with the disease and found that the genetic structure of the regions associated with Crohn’s disease risk in the Ashkenazi Jewish group was much less diverse than that of non-Jewish Europeans.

With this new data, researchers hope analyze the specific signals to pinpoint causal genetic mutations, discover why they are malfunctioning, and eventually develop new treatments.

New Israeli Study Links Alzheimer's to Brain Hyperactivity New Israeli Study Links Alzheimer's to Brain Hyperactivity TrendingCanadians Learn How Bar-Ilan University Cares for Traumatized Families During Operation Protective Edge Canadians Learn How Bar-Ilan University Cares for Traumatized Families During Operation Protective Edge TrendingBelgian Doctor Refuses to Treat Jewish Patient Belgian Doctor Refuses to Treat Jewish Patient Trending
 

Spike Jonze to Guest Star on HBO’s ‘Girls’

August 01, 2014 | By Ashley Baylen
Spike Jonze to Guest Star on HBO’s ‘Girls’

The 'Her' director is joining an ever-growing list of celebrity guests stars

Read More

Drake Announces OVO Pop-Up Shop in Toronto During Music Festival [PHOTOS]

August 01, 2014 | By Ashley Baylen
Drake Announces OVO Pop-Up Shop in Toronto During Music Festival [PHOTOS]

A new clothing line will be premiered on Friday in Drake's hometown

Read More

Sarah Michelle Gellar to Host Mattel Party For Children’s Hospital

August 01, 2014 | By Ashley Baylen
Sarah Michelle Gellar to Host Mattel Party For Children’s Hospital

Mattel Children's Hospital UCLA is celebrating its 15th annual Mattel Party on the Pier.

Read More

Autism in the IDF: Meet the Soldiers of Intelligence Unit 9900

August 01, 2014 | By IDF Blog
Autism in the IDF: Meet the Soldiers of Intelligence Unit 9900

Special intelligence Unit 9900 is dedicated to everything related to geography, including mapping, interpretation of aerial and satellite photographs and space research.

Read More

Israel's Farmigo App Lets You Buy Food Straight from Local Farmers

August 01, 2014 | By Dyana So, NoCamels
Israel's Farmigo App Lets You Buy Food Straight from Local Farmers

Farmigo is more than just another eco-friendly startup embracing technology to improve lifestyles

Read More

New Israeli Study Links Alzheimer's to Brain Hyperactivity

August 01, 2014 | By Viva Sarah Press
New Israeli Study Links Alzheimer's to Brain Hyperactivity

Research offers the potential for restoring memory and protecting the brain of patients with this debilitating disease

Read More

How Humanitarian Pressure Helped Create Israel’s Terror Tunnel Problem

August 01, 2014 | By Josh Hasten
How Humanitarian Pressure Helped Create Israel’s Terror Tunnel Problem

Experts claim that pressure was mounting on Israel to transfer building materials, which, in a way, helped Hamas' efforts

Read More

US: Release Abducted Soldier

August 01, 2014 | By Ynet News
US: Release Abducted Soldier

Kerry speaks with Netanyahu, White House slams Hamas attack as 'barbaric' violation of ceasefire

Read More

More Headlines