Shalom Life | October 20, 2014

Study Sheds Light on Crohn’s Disease in Ashkenazi Jews

Five New Genetic Mutations Discovered

By: Leonard Carl

Published: May 15th, 2012 in Health » World

Study Sheds Light on Crohn’s Disease in Ashkenazi Jews

Ashkenazi Jews are four times more likely to be affected by Crohn’s disease than any other group.

Crohn’s is an inflammatory bowel disease (IBD) which affects the intestines, but may occur anywhere from the mouth to the anus. While the exact cause of Crohn's disease is unknown, we do know that it’s an autoimmune disorder which occurs when the body's immune system mistakenly attacks and destroys healthy body tissue.

Up until now, the reason for the high likelihood of infection within the Ashkenazi group was unknown, but according to an online science journal, researchers have shed light on this phenomenon with the discovery of five new genetic mutations.

According to the March 8th issue of PLoS (Public Library of Science), Prof. Inga Peter, a geneticist at Mount Sinai, led an international research team to search for unique genetic risk factors in Ashkenazi Jews. Peter and her team compared 1,878 Ashkenazi Jews with Crohn’s disease with 4,469 Ashkenazi Jews without it, using DNA samples to determine their genetics. The team found 12 of the known risk variants, but also uncovered five new genetic risk regions on chromosomes (5q21.1, 2p15, 8q21.11, 10q26.3 and 11q12.1).

Funded by the New York Crohn’s Disease foundation, the research team also evaluated previous findings in non- Jewish Europeans with the disease and found that the genetic structure of the regions associated with Crohn’s disease risk in the Ashkenazi Jewish group was much less diverse than that of non-Jewish Europeans.

With this new data, researchers hope analyze the specific signals to pinpoint causal genetic mutations, discover why they are malfunctioning, and eventually develop new treatments.

Israeli Study Says Diet Soda Can Lead to Diabetes and Obesity Israeli Study Says Diet Soda Can Lead to Diabetes and Obesity TrendingIsraeli Hospital Treats Hamas Leader's Daughter Israeli Hospital Treats Hamas Leader's Daughter TrendingMark Zuckerberg Donates $25 Million to Ebola Research Mark Zuckerberg Donates $25 Million to Ebola Research Trending
 

Sleater-Kinney is Back Together After 10 Years

October 20, 2014 | By Ashley Baylen
Sleater-Kinney is Back Together After 10 Years

The band is releasing their first album since 2005 and going on tour.

Read More

The Nosh Pit: Vegan Soups and Stews

October 20, 2014 | By Sara Torvik
The Nosh Pit: Vegan Soups and Stews

What's better than comforting and healthy soups and stews on these damp and rainy days?

Read More

Jerry Seinfeld Honors Jay Leno, Wonders Where His Mark Twain Prize Is

October 20, 2014 | By Sara Torvik
Jerry Seinfeld Honors Jay Leno, Wonders Where His Mark Twain Prize Is

Seinfeld was one of many comedians that celebrated the former 'Tonight Show' host

Read More

'The Real Housewives of New York' Welcomes Back Bethenny Frankel

October 20, 2014 | By Sara Torvik
'The Real Housewives of New York' Welcomes Back Bethenny Frankel

The Skinnygirl founder will be returning for the seventh season of the popular reality series.

Read More

Known for Chemistry, Israeli Nobel Laureate Also Champions Tech Entrepreneurship

October 20, 2014 | By Alina Dain Sharon, JNS.org
Known for Chemistry, Israeli Nobel Laureate Also Champions Tech Entrepreneurship

Dan Shechtman, winner of the 2011 Nobel Prize in Chemistry and a candidate in last June's Israeli presidential election, has long championed technological entrepreneurship and its potential to improve lives around the world

Read More

Israeli Study Says Diet Soda Can Lead to Diabetes and Obesity

October 20, 2014 | By NoCamels Team
Israeli Study Says Diet Soda Can Lead to Diabetes and Obesity

Is this the reason why diet soda drinkers are often overweight?

Read More

Report Claims Nazi War Criminals Received Millions in U.S. Social Security Benefits

October 20, 2014 | By Daniel Koren
Report Claims Nazi War Criminals Received Millions in U.S. Social Security Benefits

Investigation by Associated Press finds that dozens of Nazis collected payments as part of a deal to force them to leave the U.S. voluntarily

Read More

Mango Under Fire For Selling 'SS Blouse'

October 20, 2014 | By Daniel Koren
Mango Under Fire For Selling 'SS Blouse'

The Jewish-founded fashion company has faced increased criticism this week after unveiling a new shirt that boasts a lightning-bolt motif

Read More

More Headlines