Shalom Life | October 20, 2014

Study Sheds Light on Crohn’s Disease in Ashkenazi Jews

Five New Genetic Mutations Discovered

By: Leonard Carl

Published: May 15th, 2012 in Health » World

Study Sheds Light on Crohn’s Disease in Ashkenazi Jews

Ashkenazi Jews are four times more likely to be affected by Crohn’s disease than any other group.

Crohn’s is an inflammatory bowel disease (IBD) which affects the intestines, but may occur anywhere from the mouth to the anus. While the exact cause of Crohn's disease is unknown, we do know that it’s an autoimmune disorder which occurs when the body's immune system mistakenly attacks and destroys healthy body tissue.

Up until now, the reason for the high likelihood of infection within the Ashkenazi group was unknown, but according to an online science journal, researchers have shed light on this phenomenon with the discovery of five new genetic mutations.

According to the March 8th issue of PLoS (Public Library of Science), Prof. Inga Peter, a geneticist at Mount Sinai, led an international research team to search for unique genetic risk factors in Ashkenazi Jews. Peter and her team compared 1,878 Ashkenazi Jews with Crohn’s disease with 4,469 Ashkenazi Jews without it, using DNA samples to determine their genetics. The team found 12 of the known risk variants, but also uncovered five new genetic risk regions on chromosomes (5q21.1, 2p15, 8q21.11, 10q26.3 and 11q12.1).

Funded by the New York Crohn’s Disease foundation, the research team also evaluated previous findings in non- Jewish Europeans with the disease and found that the genetic structure of the regions associated with Crohn’s disease risk in the Ashkenazi Jewish group was much less diverse than that of non-Jewish Europeans.

With this new data, researchers hope analyze the specific signals to pinpoint causal genetic mutations, discover why they are malfunctioning, and eventually develop new treatments.

Israeli Study Says Moviegoers And Schizophrenics Share Similar Brain Activity Israeli Study Says Moviegoers And Schizophrenics Share Similar Brain Activity TrendingMark Zuckerberg Donates $25 Million to Ebola Research Mark Zuckerberg Donates $25 Million to Ebola Research TrendingReport: Hitler Was A Meth Addict Report: Hitler Was A Meth Addict Trending
 

The Ten Best Spielberg Flicks Every Film Lover Needs To See

October 17, 2014 | By Caitlin Marceau
The Ten Best Spielberg Flicks Every Film Lover Needs To See

Spielberg has directed over 50 films and produced more than 140. How can you possibly narrow his masterpieces down to just 10? We somehow managed to.

Read More

Six Israelis Dead, 12 Still Missing After Avalanche in Nepal

October 17, 2014 | By Caitlin Marceau
Six Israelis Dead, 12 Still Missing After Avalanche in Nepal

A freak storm and several avalanches leave dozens dead, including several Israeli tourists.

Read More

Israel's Ben-Gurion Put Through Ebola Drill

October 17, 2014 | By Caitlin Marceau
Israel's Ben-Gurion Put Through Ebola Drill

The Israeli government is encouraging Ebola simulations be practiced to prevent the possible spread of the virus.

Read More

Etsy Called Out For Selling Anti-Semitic Paraphernalia

October 17, 2014 | By Caitlin Marceau
Etsy Called Out For Selling Anti-Semitic Paraphernalia

The online vendor has been called out for selling almost 1000 items emblazoned with swastikas or Hitler's likeness.

Read More

Islamic State Being Trained to Fly Captured Fighter Jets

October 17, 2014 | By Sara Torvik
Islamic State Being Trained to Fly Captured Fighter Jets

In Syria, it is being reported that Iraqi pilots who have joined the Islamic State are training members of the group to fly in three captured fighter jets.

Read More

Charlie Sheen Calls Off Engagement to Porn Star

October 17, 2014 | By Sara Torvik
Charlie Sheen Calls Off Engagement to Porn Star

Sheen explains that although the couple had fun, they don't want to spend the rest of their lives together.

Read More

Montreal Boutique Sells Hitler With an Afro Shirt

October 17, 2014 | By Sara Torvik
Montreal Boutique Sells Hitler With an Afro Shirt

The t-shirt is captioned with the phrase "Too fast to live, too young to die."

Read More

Spain Will Vote to Recognize Palestinian State

October 17, 2014 | By Sara Torvik
Spain Will Vote to Recognize Palestinian State

This news comes on the heels of the British parliament voting overwhelmingly in favour of a non-binding motion to support recognition of a Palestinian state on Monday.

Read More

More Headlines