Shalom Life | October 31, 2014

Study Sheds Light on Crohn’s Disease in Ashkenazi Jews

Five New Genetic Mutations Discovered

By: Leonard Carl

Published: May 15th, 2012 in Health » World

Study Sheds Light on Crohn’s Disease in Ashkenazi Jews

Ashkenazi Jews are four times more likely to be affected by Crohn’s disease than any other group.

Crohn’s is an inflammatory bowel disease (IBD) which affects the intestines, but may occur anywhere from the mouth to the anus. While the exact cause of Crohn's disease is unknown, we do know that it’s an autoimmune disorder which occurs when the body's immune system mistakenly attacks and destroys healthy body tissue.

Up until now, the reason for the high likelihood of infection within the Ashkenazi group was unknown, but according to an online science journal, researchers have shed light on this phenomenon with the discovery of five new genetic mutations.

According to the March 8th issue of PLoS (Public Library of Science), Prof. Inga Peter, a geneticist at Mount Sinai, led an international research team to search for unique genetic risk factors in Ashkenazi Jews. Peter and her team compared 1,878 Ashkenazi Jews with Crohn’s disease with 4,469 Ashkenazi Jews without it, using DNA samples to determine their genetics. The team found 12 of the known risk variants, but also uncovered five new genetic risk regions on chromosomes (5q21.1, 2p15, 8q21.11, 10q26.3 and 11q12.1).

Funded by the New York Crohn’s Disease foundation, the research team also evaluated previous findings in non- Jewish Europeans with the disease and found that the genetic structure of the regions associated with Crohn’s disease risk in the Ashkenazi Jewish group was much less diverse than that of non-Jewish Europeans.

With this new data, researchers hope analyze the specific signals to pinpoint causal genetic mutations, discover why they are malfunctioning, and eventually develop new treatments.

Dry California Welcomes Israeli Water Expert Dry California Welcomes Israeli Water Expert TrendingUN Lauds Israel's 'Critical Support' in Fighting Ebola UN Lauds Israel's 'Critical Support' in Fighting Ebola TrendingIsraeli Study: Quitting Smoking Will Make You Physically Stronger Israeli Study: Quitting Smoking Will Make You Physically Stronger Trending
 

Dry California Welcomes Israeli Water Expert

October 31, 2014 | By Daniel Koren
Dry California Welcomes Israeli Water Expert

'As an issue of national security, Israel has successfully made itself water independent,' says California Natural Resources Agency Secretary John Laird

Read More

Op-Ed: CUNY Is No Place For BDS Movement’s Hate

October 31, 2014 | By Jacob Baime, JNS.org
Op-Ed: CUNY Is No Place For BDS Movement’s Hate

Last week, the doctoral students council of CUNY once again considered a hateful resolution, calling for a boycott of Israeli academic institutions

Read More

Lieberman to Sweden: Middle East Relations More Complex Than Assembling IKEA Furniture

October 31, 2014 | By Ynet News
Lieberman to Sweden: Middle East Relations More Complex Than Assembling IKEA Furniture

Swedish Foreign Minister Margot Wallstrom disagrees

Read More

Lena Dunham and Celebrity BFF’s Raise Awareness For Planned Parenthood

October 30, 2014 | By Ashley Baylen
Lena Dunham and Celebrity BFF’s Raise Awareness For Planned Parenthood

The 'Girls' creator has designed a shirt for the women's rights organization

Read More

Seth Rogen Will Play Steve Wozniak in New Steve Jobs Bio Pic

October 30, 2014 | By Ashley Baylen
Seth Rogen Will Play Steve Wozniak in New Steve Jobs Bio Pic

Rogen is in negotiations to star as the Apple co-founder alongside Christian Bale

Read More

A New Pee-Wee Herman Movie Has Been Confirmed

October 30, 2014 | By Ashley Baylen
A New Pee-Wee Herman Movie Has Been Confirmed

Paul Reubens told Jimmy Fallon that Judd Apatow will be producing the reboot

Read More

Breakthrough Jew - Joshua Meier

October 30, 2014 | By Sara Torvik
Breakthrough Jew - Joshua Meier

18-year-old Meier won the Best in Category Award in cellular and molecular biology at the 2014 Intel International Science and Engineering Fair for his work in harnessing the aging process to treat diseases.

Read More

Startup Club: Cat2See

October 30, 2014 | By Caitlin Marceau
Startup Club: Cat2See

The Israeli company has created an app that lets you play with your cats, monitor them, and even feed them when you're not home

Read More

More Headlines