Shalom Life | December 21, 2014

Study Sheds Light on Crohn’s Disease in Ashkenazi Jews

Five New Genetic Mutations Discovered

By: Leonard Carl

Published: May 15th, 2012 in Health » World

Study Sheds Light on Crohn’s Disease in Ashkenazi Jews

Ashkenazi Jews are four times more likely to be affected by Crohn’s disease than any other group.

Crohn’s is an inflammatory bowel disease (IBD) which affects the intestines, but may occur anywhere from the mouth to the anus. While the exact cause of Crohn's disease is unknown, we do know that it’s an autoimmune disorder which occurs when the body's immune system mistakenly attacks and destroys healthy body tissue.

Up until now, the reason for the high likelihood of infection within the Ashkenazi group was unknown, but according to an online science journal, researchers have shed light on this phenomenon with the discovery of five new genetic mutations.

According to the March 8th issue of PLoS (Public Library of Science), Prof. Inga Peter, a geneticist at Mount Sinai, led an international research team to search for unique genetic risk factors in Ashkenazi Jews. Peter and her team compared 1,878 Ashkenazi Jews with Crohn’s disease with 4,469 Ashkenazi Jews without it, using DNA samples to determine their genetics. The team found 12 of the known risk variants, but also uncovered five new genetic risk regions on chromosomes (5q21.1, 2p15, 8q21.11, 10q26.3 and 11q12.1).

Funded by the New York Crohn’s Disease foundation, the research team also evaluated previous findings in non- Jewish Europeans with the disease and found that the genetic structure of the regions associated with Crohn’s disease risk in the Ashkenazi Jewish group was much less diverse than that of non-Jewish Europeans.

With this new data, researchers hope analyze the specific signals to pinpoint causal genetic mutations, discover why they are malfunctioning, and eventually develop new treatments.

Israeli Study: Kids Start Enjoying the Misfortune of Others At Very Early Age Israeli Study: Kids Start Enjoying the Misfortune of Others At Very Early Age TrendingIsraeli Researchers: We're Most Likely Alone in the Universe Israeli Researchers: We're Most Likely Alone in the Universe TrendingIsrael Hailed As A World Leader in Medical Tourism Israel Hailed As A World Leader in Medical Tourism Trending
 

Top 50 Hottest Jewish Women of 2014 (30-21)

December 19, 2014 | By Ashley Baylen
Top 50 Hottest Jewish Women of 2014 (30-21)

Join Shalom Life in celebrating the 50 most talented, intelligent, funny, and beautiful Jewish women of the year.

Read More

Analyst Suggests Qatar 'Give' World Cup 2022 to Gaza

December 19, 2014 | By Daniel Koren
Analyst Suggests Qatar 'Give' World Cup 2022 to Gaza

Tom Gross argues that the move would be beneficial for Palestinians in Israel

Read More

Natalie Portman Explains How 'Star Wars' Almost Ruined Her Career

December 19, 2014 | By Sara Torvik
Natalie Portman Explains How 'Star Wars' Almost Ruined Her Career

The 'Black Swan' actress says no one wanted to work with her after 'Star Wars'

Read More

Liberace's Hologram to Go On World Tour, Starting in Las Vegas

December 19, 2014 | By Sara Torvik
Liberace's Hologram to Go On World Tour, Starting in Las Vegas

The deceased performer will be entertaining a whole new generation of fans.

Read More

Adam Levine's Maroon 5 Rock Out at The People Magazine Awards [VIDEO]

December 19, 2014 | By Sara Torvik
Adam Levine's Maroon 5 Rock Out at The People Magazine Awards [VIDEO]

On Thursday evening, Maroon 5 wowed the audience with a live performance of 'Animals'

Read More

Oops! Drake Confused Adam Silver for Donald Sterling

December 19, 2014 | By Sara Torvik
Oops! Drake Confused Adam Silver for Donald Sterling

At the Toronto Raptors Drake night, Drake mixed up some important names.

Read More

Ambassador Dan Shapiro Urges U.S. Collaboration with Jerusalem College of Technology

December 19, 2014 | By ShalomLife Team
Ambassador Dan Shapiro Urges U.S. Collaboration with Jerusalem College of Technology

Shapiro visited the college for a private demonstration of several ground-breaking technologies developed by students

Read More

This British Politician Is Trying to Put an End to Racism & anti-Semitism on Twitter

December 19, 2014 | By Daniel Koren
This British Politician Is Trying to Put an End to Racism & anti-Semitism on Twitter

Luciana Berger, the subject of some 2,500 anti-Semitic tweets earlier this year, wants the platform to ban racist words

Read More

More Headlines