Shalom Life | July 23, 2014

Study Sheds Light on Crohn’s Disease in Ashkenazi Jews

Five New Genetic Mutations Discovered

By: Leonard Carl

Published: May 15th, 2012 in Health » World

Study Sheds Light on Crohn’s Disease in Ashkenazi Jews

Ashkenazi Jews are four times more likely to be affected by Crohn’s disease than any other group.

Crohn’s is an inflammatory bowel disease (IBD) which affects the intestines, but may occur anywhere from the mouth to the anus. While the exact cause of Crohn's disease is unknown, we do know that it’s an autoimmune disorder which occurs when the body's immune system mistakenly attacks and destroys healthy body tissue.

Up until now, the reason for the high likelihood of infection within the Ashkenazi group was unknown, but according to an online science journal, researchers have shed light on this phenomenon with the discovery of five new genetic mutations.

According to the March 8th issue of PLoS (Public Library of Science), Prof. Inga Peter, a geneticist at Mount Sinai, led an international research team to search for unique genetic risk factors in Ashkenazi Jews. Peter and her team compared 1,878 Ashkenazi Jews with Crohn’s disease with 4,469 Ashkenazi Jews without it, using DNA samples to determine their genetics. The team found 12 of the known risk variants, but also uncovered five new genetic risk regions on chromosomes (5q21.1, 2p15, 8q21.11, 10q26.3 and 11q12.1).

Funded by the New York Crohn’s Disease foundation, the research team also evaluated previous findings in non- Jewish Europeans with the disease and found that the genetic structure of the regions associated with Crohn’s disease risk in the Ashkenazi Jewish group was much less diverse than that of non-Jewish Europeans.

With this new data, researchers hope analyze the specific signals to pinpoint causal genetic mutations, discover why they are malfunctioning, and eventually develop new treatments.

Israeli Surgeons Treat Palestinian Girl While Under Fire Israeli Surgeons Treat Palestinian Girl While Under Fire TrendingRadiation Therapy Is About to get Much Kinder Radiation Therapy Is About to get Much Kinder TrendingPalestinians Continue to Receive Medical Care in Israel Palestinians Continue to Receive Medical Care in Israel Trending
 

Shaw Festival Review: THE SEA

July 23, 2014 | By Hermine Steinberg
Shaw Festival Review: THE SEA

The Sea is a well acted, interesting play that at times tries too hard to make a point we know all too well.

Read More

Billy Joel To Be Honored With Gershwin Prize By Library Of Congress

July 23, 2014 | By Ashley Baylen
Billy Joel To Be Honored With Gershwin Prize By Library Of Congress

The 'Piano Man' will receive the prize in Washington this November.

Read More

Jon Stewart Launches $10 Billion Kickstarter Page to Buy CNN

July 23, 2014 | By Ashley Baylen
Jon Stewart Launches $10 Billion Kickstarter Page to Buy CNN

'The Daily Show' host isn't sure what he'll do with the network once it's purchased.

Read More

Jake Gyllenhaal’s ‘Nightcrawler’ Gets First Trailer [VIDEO]

July 23, 2014 | By Ashley Baylen
Jake Gyllenhaal’s ‘Nightcrawler’ Gets First Trailer [VIDEO]

Dan Gilroy's debut film will premiere at TIFF in September

Read More

Jewish Hall Of Fame: Neil Diamond

July 23, 2014 | By Caitlin Marceau
Jewish Hall Of Fame: Neil Diamond

The Grammy-award winning singer is the third most successful adult contemporary artist on the Billboard charts behind Barbra Streisand and Elton John

Read More

James Franco’s ‘Of Mice And Men’ Is Coming To a Theatre Near You

July 23, 2014 | By Ashley Baylen
James Franco’s ‘Of Mice And Men’ Is Coming To a Theatre Near You

The popular Broadway production is set to be filmed for a wider audience

Read More

Jon Stewart Parodies His Critics for Calling Him “Pro-Hamas” [VIDEO]

July 23, 2014 | By Peter Herriman
Jon Stewart Parodies His Critics for Calling Him “Pro-Hamas” [VIDEO]

Stewart has been in political hot water since last week's show where he called out Israel for how its handling the crisis in Gaza

Read More

Belgian Café Posts "No Jews Allowed" Sign

July 23, 2014 | By Peter Herriman & Daniel Koren
Belgian Café Posts "No Jews Allowed" Sign

The Belgian League Against Anti-Semitism has since filed a complaint against the parties responsible

Read More

More Headlines